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Upon the arrival of Columbus in 1492 in the Carabean Islands, unknown to Columbus (and majority of the Eastern Hemisphere), he landed on Islands located in the middle of two huge continents now known has North America and South America that was teaming with huge Civilizations (that rivaled any in the world at that time) and thousands of smaller Nations and Tribes. With recent estimations, the population may have been over 100 million people that spanned from Alaska and Green Land, all the to the tip of southern South America.
Pre Colombian North America (north of Mesoamerica):
In Pre-Canada, most people lived along the coast, along the major rivers