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World renowned functional medicine doctor, Peter Osborne, discusses leaky gut solutions and help.
Leaky Gut Syndrome -- Is Gluten at the Root?
Research Review Shows That Gluten Causes Leaky Gut
The primary functions of the gastrointestinal tract have traditionally been perceived to be limited to the digestion and absorption of nutrients and to electrolytes and water homeostasis. A more attentive analysis of the anatomic and functional arrangement of the gastrointestinal tract, however, suggests that another extremely important function of this organ is its ability to regulate the trafficking of macromolecules between the environment and the host through a barrier mechanism. Together with the gut-associated lymphoid tissue and the neuroendocrine network, the intestinal epithelial barrier, with its intercellular tight junctions, controls the equilibrium between tolerance and immunity to non-self antigens. Zonulin is the only physiological modulator of intercellular tight junctions described so far that is involved in trafficking of macromolecules and, therefore, in tolerance/immune response balance. When the finely tuned zonulin pathway is deregulated in genetically susceptible individuals, both intestinal and extraintestinal autoimmune, inflammatory, and neoplastic disorders can occur. This new paradigm subverts traditional theories underlying the development of these diseases and suggests that these processes can be arrested if the interplay between genes and environmental triggers is prevented by reestablishing the zonulin-dependent intestinal barrier function.
Physiol Rev. 2011 Jan;91(1):151-75.
Leaky Gut in Layman's Terms
I was recently interviewed by Leaky Gut expert, Karen Brimeyer. We discussed the ins and outs of this intestinal affliction in an easy to understand manner.
Dr. Fasano Discovered Leaky Gut
Multiple research studies have linked gluten to the condition known as intestinal permeability - I recently had the privilege of speaking with one of the leading gluten sensitivity researchers in the world, Dr. Alessio Fasano. He is the head of research at the University of Maryland Celiac Research Center, and he is responsible for discovering the gluten/leaky gut connection. In this video, we discuss how this condition can affect the gut, the brain, and multiple other tissues in the body...
Making the Connection -- The Gluten Free Warrior's Stance:
Most people assume that celiac disease and gluten sensitivity are the same thing. Fortunately, this archaic thought is rapidly changing as new research has proven that gluten sensitivity exists independently of celiac disease. Although it is well established that gluten often impacts the villi of the small intestine, it has also been shown to affect the body in multiple ways. These differences account for the massive failure of doctors to diagnose gluten sensitivity. Below is a diagram of environmental triggers to intestinal permeability (leaky gut). You will find that gluten sensitivity can directly and indirectly contribute to this problem. To the intelligent observer, this picture illustrates why simple antibody testing fails to accurately diagnosis gluten sensitivity. Antibody production is only one lab component of a multi-faceted problem.